To construct MAPN, AMP (KLA) and PD‐L1 antagonist peptide (CVR) were first conjugated onto PDPA with a disulfide bond or thioketal bond, and then self‐assembled with a detachable PEGylated polymer, which enables MAPN to avoid immune clearance during blood circulation and efficiently accumulate at tumor tissues. The gene discussed is CD274; the disease is neoplasm.