The Mendelian randomisation-derived odds ratio for CHD for a 50 nmol/L higher Lp(a)-apoB was 1.28 [95% confidence interval (CI):1.24-1.33] compared to 1.04 [95%CI:1.03-1.05] for the same increment in LDL-apoB. This evidence concerns the gene APOB and coronary artery disorder.