A number of investigations, based on the relationship of genetically-predicted variation in Lp(a) to CHD risk, have yielded answers that vary considerably 11–14, and indicate that Lp(a) mass concentration would need to be lowered by 50-100 mg/dL to achieve the same risk reduction as a 1.0 mmol/L lower LDL cholesterol (LDL-C). Here, LPA is linked to coronary artery disorder.