We compared these clusters to other published AML subtypes and found that the transcriptional signature (Figure 1E) of cluster 2 captured signaling pathways (RHO GTPase, FCGR, and NFKB activation), whereas the protein signatures captured RNA splicing and processing and mitochondria-related signatures (Figure 1F), which aligns with Jayavelu et al.,18 who observed enrichment of mitochondria-related signatures only at the protein level. This evidence concerns the gene FCGR2A and acute myeloid leukemia.