Next, we tested the association between rs76580947 and hepatic IL32 mRNA levels in 207 individuals from the Molecular Architecture of FAtty Liver Disease in individuals with obesity undergoing bAriatric surgery (MAFALDA) cohort (from central Italy) and we found that carriers of the variant have lower IL32 mRNA levels (Figure 7B). Here, IL32 is linked to obesity due to melanocortin 4 receptor deficiency.