Of the 28 NS orthologous mutations implicated in human gliomas, 24 were classified as pathogenic in COSMIC and 17 have conserved amino acid change for rat and human including Tp53 [p.140P>L, p.142Q>*, p.149P>L, p.156R>C, p.260G>V, p.271R>C], Nf1 [p.192R>*, p.379C>Y, p.436S>L, p.440R>*, p.758Q>*, p.1080S>L], Erbb2 p.39P>S, Egfr p.596P>S, Pik3r1 p.464D>N, Cdkn2a p.26A>T and Arid1a p.>E. Here, PIK3R1 is linked to central nervous system cancer.