Greater than 50% of variants in Cdkn2a, Erbb2, Pik3r1 and Tp53 and less than 50% in Arid1a, Braf, Egfr, Nf1, Pdgfra and Pik3ca were described in COSMIC for both brain and heart tumors (S2 and S4 Tables). The gene discussed is PIK3R1; the disease is heart neoplasm.