Duchenne musculardystrophy (DMD) is caused by a nonsense mutation in the DMD gene encoding dystrophin, leading to progressive muscle weakness.It is an example of a monogenic disease arising from unwanted terminationat a UAA stop-codon site (a so-called premature termination codon(PTC)) that leads to truncated gene products. This evidence concerns the gene DMD and Duchenne muscular dystrophy.