However, IEIs associated with autoantibodies to type I IFN (hereafter referred to as autoantibodies), e.g., AIRE variants causing autoimmune polyglandular syndrome type 1 (APS-1), significantly increased the risk of life-threatening disease after SARS-CoV-2 infection [52–54]. The gene discussed is AIRE; the disease is autoimmune polyendocrine syndrome type 1.