HDAC9 and acute leukemia: It was recently shown that the survival of AZD1775-resistant acute leukemia cell lines relied on the activity of MYC and HDAC, which was in part due to the increased KDM5A activity (Garcia et al. 2020), thus corroborating preclinical studies that advocate for the combined utilization of WEE1 and HDAC inhibitors (Qi et al. 2015; Tanaka et al. 2017; Zhou et al. 2015).