While guanylate-binding proteins (GBPs) facilitate Casp11 activation in response to bacterial infection (Man et al., 2016; Meunier et al., 2014; Pilla et al., 2014; Wandel et al., 2020), and in some settings, NLRP3-dependent detection of bacterial mRNA potentiates Casp11 activation (Moretti et al., 2022), Casp11 contains all of the properties of an inflammasome sensor, adaptor, and effector within a single protein. This evidence concerns the gene NLRP3 and bacterial infectious disease.