The general pharmacological effects on human papillary thyroid cancer cells that are related to the activation of Sestrin2 (SESN2), upregulated p‐AMPK (phosphorylated AMPK), and inhibits p‐mTOR (phosphorylated mTOR) and p‐p70S6Kinase (ribosomal protein S6 kinase).66 Here, SESN2 is linked to thyroid gland papillary carcinoma.