Another study led by Zhao X. showed that ER‐β, a mediator of the stimulation of ER‐alpha, IGF‐1R, p‐Akt, and miR‐95 expression, can suppress the proliferation of CRC cells caused by calycosin (0–80 μM) in both in vitro and in vivo model.69 This evidence concerns the gene AKT1 and colorectal carcinoma.