conducted a study on BALB/c nude mice at various doges (30–120 mg/kg) and found that calycosin reduced tumor weight via downregulating MPP2, IκBα and ECT2, IL‐6 signaling components, simultaneously activate apoptosis, suppressed cell proliferation, metastasis, and cell growth at various doges (60–180 μmol/L) in 143B human cell line.101. This evidence concerns the gene MPP2 and neoplasm.