reported that calycosin mediates anti‐cancer properties, including inhibiting growth and inducing apoptosis by targeting estrogen receptor beta (ER‐β) in numerous breast cancer cells by suppressing IGF‐1R, combined with the selective modulation of MAPK and phosphatidylinositol 3‐kinase (PI3K)/Akt pathways.48 The gene discussed is ESR2; the disease is breast cancer.