ESR2 and colorectal carcinoma: Another study led by Zhao X. showed that ER‐β, a mediator of the stimulation of ER‐alpha, IGF‐1R, p‐Akt, and miR‐95 expression, can suppress the proliferation of CRC cells caused by calycosin (0–80 μM) in both in vitro and in vivo model.69