Calycosin promotes apoptosis by reducing the expression of the anti‐apoptotic protein Bcl‐2 and raising the expression of pro‐apoptotic proteins Bax, caspase‐3, and PARP and stopping the cell cycle in the G0/G1 phase through signaling pathways like MAPK, STAT3, NF‐κB, and AKT at hepatocellular carcinoma (HCC) cell lines.76 This evidence concerns the gene NFKB1 and hepatocellular carcinoma.