Pathogenic variants (PV) of the tumor protein p53 (TP53) gene are associated with the Li‐Fraumeni syndrome (LFS), which is currently gaining clinical attention even though it occurs by far less frequently than the Hereditary Breast and Ovarian Cancer (HBOC) syndrome (Li 1988, Ford 1998). The gene discussed is TP53; the disease is Li-Fraumeni syndrome.