AKT1 and obesity due to melanocortin 4 receptor deficiency: The former manifest at a younger age and are linked to obesity, lipid, and metabolic disorders, are estrogen-dependent and related to a thickened endometrium, bear endometrioid histology, have molecular associations with PTEN, MSI, PI3K/AKT, and KRAS, and generally portend a good prognosis.