In premenopausal women, there seems to be an inverse association of estrogen receptors (ER+ cancers) with obesity (as per BMI and per adiposity), a positive correlation between obesity and triple-negative cancers (43-80% higher risk), and a nonsignificant association between HER2+ status and obesity 28. This evidence concerns the gene ERBB2 and obesity due to melanocortin 4 receptor deficiency.