ESR1 and neoplasm: Furthermore, the top 9 interacting hub genes including AKT1, VEGFA, EGFR, TP53, CASP3, JUN, MAPK3, STAT3 and ESR1, were obtained based on three core networks using the CtyoNCA plugin of Cytoscape (Figure 5C), which was identified as key hub proteins and may play an important role in the efficacy of TBMS1 in the treatment of tumor microvessels.