STAT3 and neoplasm: In the above “virtual studies” results, as VEGFA-VEGFR2 signaling pathways has been reported to participation in antiangiogenic effects of TBMS1 7, we focus on “locomotion” associated with tumor microvessels, such as tumor cell adhesion and trans-endothelial migration which were reported to be regulated by the hub genes AKT1, MAPK3 and STAT3 17-19.