Through different secreted factors, such as MIF and MDK, they participated in the regulation of various subtypes of Endothelial cells, Fibroblast cells, NK/T cells, and Myeloid cells, including C1Q+ macrophages (MIF-CD74/CXCR4, MIF-CD74/CD44, MDK-NCL, etc.), CXCL3+ macrophages (MIF-CD74/CXCR4, MIF-CD74/CD44, MDK-NCL, etc.), cancer-associated fibroblasts (CAFs) (F2-F2R, MDK-SDC2, MDK-NCL, etc.), Cytotoxic CD8+ cells (MIF-CD74/CXCR4, MIF-CD74/CD44, MDK-NCL, etc.), and Dendritic cells (MIF-CD74/CXCR4, MIF-CD74/CD44, etc.). Here, CXCR4 is linked to cancer.