USP7 and cancer: Furthermore, it plays an essential role in WASH-mediated intracellular actin assembly and protein cycle.2Previously, USP7 has been shown to regulate ubiquitination of proteins, which is important for DNA repair, transcription, and cancer.3, 4The dysregulation of ubiquitin–proteasome system is implicated in the pathogenesis of numerous human diseases, including cancer and neurodegenerative diseases, and viral diseases.5USP7 plays a key role in crucial intracellular processes, including epigenetic regulation, cell cycle control, cellular growth and survival.