SRRM4 and Anxiety: Based on our previous observation that bv/bv mice show increased anxiety and a decreased number of GABAergic interneurons in specific areas of the cortex at 3–4 months of age (Matsuda et al., 2011), we hypothesized that Srrm4 is expressed in the interneurons, and that the bv mutation in Srrm4 results in either developmental failure or postnatal degeneration of interneurons.