Mice deficient in the 65-kDa isoform of glutamic acid decarboxylase (GAD65) exhibit increased anxiety-like behaviors (Kash et al., 1999), and knockout mice lacking the urokinase-type plasminogen activator receptor, which has been associated with autism, display increased anxiety and exhibit region-specific reductions in PV-containing GABAergic interneurons in the cingulate and front-parietal regions of the cerebral cortex (Powell et al., 2003, Levitt, 2005, Eagleson et al., 2010). Here, GAD2 is linked to Anxiety.