While CANTOS undoubtedly showed the relevance of IL-1β in CVD pathology in CKD IL-6, monocytes, monocyte-to-lymphocyte ratio, differentiated pro-inflammatory CD4+CD28− T cells, T h17 cells and inversely Tregs also correlate with cardiovascular events and mortality in CKD pinpointing towards a global role of the many facets of CKD-induced inflammation in CVD pathophysiology [17, 22, 26, 27]. The gene discussed is CD4; the disease is chronic kidney disease.