SCN1A and Dravet syndrome: A drug-naïve SCN1A DS mouse model demonstrated impaired sleep secondary to loss of the encoded Nav1.1 in forebrain GABAergic interneurons.34 However, some individuals reported a normal sleep profile in our cohort of exclusively SCN1A mutation-positive DS, suggesting that whilst the underlying SCN1A variant contributes to sleep disturbance, it is not the sole determinant.