RGD is found in association with various systemic diseases, such as autoimmune diseases (eg, inflammatory arthritis, connective tissue disease, vasculitis),1, -3 malignancy (especially hematologic neoplasms),4 certain drugs [eg, tumor necrosis factor (TNF) inhibitors, furosemide, angiotensin-converting enzyme inhibitors],1,5 and rare infections (coccidioidomycosis and borreliosis).6,7 The majority of patients had a systemic association prior to diagnosis.2 However, it is unclear which investigations should be carried out and if new associations were subsequently identified. Here, TNF is linked to hematopoietic and lymphoid system neoplasm.