Gain‐of‐function (GoF) mutations of EZH2 have been identified in various B‐cell lymphomas, including FL, DLBCL, and others.[2] EZH2 serves as enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which in turn requires at least SUZ12 and EED subunits for the methylation of histone H3 at lysine 27 (H3K27). Here, EZH2 is linked to diffuse large B-cell lymphoma.