Previously,studies using B cell‐specific Ezh2Y641F knock‐in mice or EZH2 silencing/inhibition in lymphoma cell lines have identified a set of PRC2 repressed genes in B‐cell lymphoma, such as p21/CDKN1A, class I and class II MHC complex components.[16, 38, 39] However, there was no report on the regulation of BMP6/7 and ACVR1 by PRC2 in B cell or lymphoma. The gene discussed is CDKN1A; the disease is B-cell non-Hodgkin lymphoma.