We also previously analyzed the upregulated genes by PRC2 inhibitors in lymphoma cells and did not noticed BMP or ACVR1, as there are hundreds of genes upregulated and the top genes with clear functional annotation usually catch more attention.[23, 40] Here the integration of the transcriptomic data with CRISPR functional screen results was critical in recognizing the importance of BMP6/7 and ACVR1 upregulation. Here, BMP6 is linked to lymphoma.