CASP12 and pulmonary fibrosis: Similarly, chlorogenic acid, a typical active components of Mori Folium, effectively improve the pulmonary fibrosis induced by BLM in mice via alleviating the expressions of collagen I and α-SMA in dose-dependent manner, and the levels of cleaved caspase-3, caspase-12, and caspase-9, but elevating the level of uncleaved PARP through downregulating the level of phosphorylation of ERK [25].