In this study, we found that MQZJFD could modulating the NF-κB/Nrf2 pathway in the lung tissues of BLM-treated rats, indicating that MQZJFD improve the pulmonary fibrosis induced by BLM in rats may via suppressing the activation of NF-κB/Nrf2 pathway. Here, NFKB1 is linked to pulmonary fibrosis.