CD274 and neoplasm: To determine whether STK24‐dependent tumor immune escape is indeed mediated by PD‐L1, we constructed PD‐L1 knockout mutants (Pd‐l1 KO) in CT26, MC38, LLC, and KPC cells via CRISPR‐Cas9‐mediated gene disruption and subsequently knocked down endogenous STK24 expression with shRNA(shStk24)‐mediated gene silencing in these cells.