In tumor cell surveillance, IFN‐γ secreted by immune cells promotes tumor cell‐clearing role in the tumor microenvironment; IFN‐γ also upregulates the expression of PD‐L1 in tumor cells and affects the efficacy of immunotherapy via STAT1/STAT3 signaling pathway.[14] Although STK24 has been reported to regulate the STAT3 pathway,[12] its function in tumor immunity remains unclear. Here, CD274 is linked to neoplasm.