WSX1 intervenes in hepatocellular carcinoma (HCC) tumorigenesis by blocking the PI3Kδ/AKT/GSK3β/PD‐L1 pathway, without affecting the proliferation of HCC cells in vitro.[35] A parallel observation reported that the P29S mutation of RAC1, RHO family small GTPase, which activates AKT without altering cell proliferation.[36] These observations, combined with our results, seem to suggest that AKT activity can be modularized and/or compartmentalized depending on cell type or the nature of stimuli. This evidence concerns the gene RAC1 and hepatocellular carcinoma.