The expression of PD‐L1 in tumor cells is mainly regulated by IFN‐γ/STAT1 signal transduction.[18] Additionally, the PI3K‐AKT signaling pathway also contributes to IFN‐γ‐induced PD‐L1 expression in tumor cells.[19] To elucidate the downstream signaling pathways underlying STK24‐mediated regulation of tumor PD‐L1, a series of key signaling protein candidates were analyzed by western blotting. This evidence concerns the gene CD274 and neoplasm.