Their functions align more with the inflammatory cancer‐associated fibroblasts, particularly the apCAFs characteristics.[106, 107, 108] pEMT, CAF1, and CAF2 cells undergo a transition from epithelial keratinization to extracellular matrix remodeling and immune response regulation through the expression of various TFs such as FOSL1, TCF4, and SPI1. This evidence concerns the gene SPI1 and cancer.