Moreover, in the study of non-small cell lung cancer develop brain metastasis (NSCLC-BM), researchers found that brain-specific metastatic cells A549-F3 induce polarization of microglia towards an M2 phenotype characterized by high expression of CD206 and Arginase-1 via the IL-6/JAK2/STAT3 signaling pathway and microglia, in turn, promote NSCLC-BM development by affecting the colonization of metastatic cells [154]. This evidence concerns the gene MRC1 and non-small cell lung carcinoma.