In response to stimulation from cancer cells, the expression of the TREM-1 increases, promoting KCs activation and HCC progression, while TREM-1 deficiency has been found to decrease the release of IL-1β, IL-6, CCL2, and CXCL10 by KCs, resulting in suppressed HCC growth [97]. Here, TREM1 is linked to hepatocellular carcinoma.