Furthermore, the delivery of Parkin RING0 domain or a Parkin mini-peptide within the RING0 domain involved in this specific protein–protein interaction can rescue compromised mitochondrial function in Parkin-deficient neuroblastoma SH-SY5Y cells and in hiPSC-derived neurons harboring disease-causing PRKN mutations. The gene discussed is PRKN; the disease is neuroblastoma.