HSIL‐O7 and HSIL‐O18 derived line harbored mutations in the tumor suppressor gene MUC16, which has recently been reported to be mutated in cervical cancer.[18] Additionally, the HSIL‐O7 cell line showed evidence of alterations in PRUNE2, which plays multiple roles in cell cycle progression, cytokinesis, and apoptosis (Figure 4C). This evidence concerns the gene PRUNE2 and cervical cancer.