HSIL‐O7 and HSIL‐O18 derived line harbored mutations in the tumor suppressor gene MUC16, which has recently been reported to be mutated in cervical cancer.[18] Additionally, the HSIL‐O7 cell line showed evidence of alterations in PRUNE2, which plays multiple roles in cell cycle progression, cytokinesis, and apoptosis (Figure 4C). Here, MUC16 is linked to cervical carcinoma.