In response, the unfolded protein response (UPR) is activated to restore ER homeostasis and adapt to tumor development mainly through three pathways, including inositol-requiring enzyme 1α (IRE1α), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) [8]. The gene discussed is ATF6; the disease is neoplasm.