To examine whether TRAF4‐mediated LAMTOR1 ubiquitination has any function in vivo in an inflammation‐induced CRC mouse model that has been shown to be inhibited by the mTORC1 pathway,[37] we examined the effect of TRAF4 KO (TRAF4 −/−) mice using an azoxymethane (AOM)/dextran sodium sulfate (DSS)‐induced colon cancer model (Figure 6A). The gene discussed is LAMTOR1; the disease is colorectal carcinoma.