This result was confirmed by the CRISPR‐Cas9‐based (KO) of TRAF4 (TRAF4−/−) in HEK293T, and we also confirmed in CRC cell lines, such as SW480, RKO, SW620 and HT29 (Figure 4A; Figure S4C–F, Supporting Information). The gene discussed is TRAF4; the disease is colorectal carcinoma.