Among these signaling pathways, the p53 pathway mediates the regulation of ovarian granulosa cell apoptosis by mRNA molecules, which in turn is involved in the pathogenesis of ovarian-related diseases, such as premature ovarian failure and polycystic ovary syndrome (PCOS) [49, 50]; the PI3K-Akt pathway mediates and regulates biological processes, such as cell proliferation and metabolism and the maintenance of genomic integrity, which in turn affects the recruitment and growth of primordial follicles. This evidence concerns the gene AKT1 and polycystic ovary syndrome.