Their biological processes and pathways were involved in Hippo and MAPK signalling pathways, neurogenesis and ubiquitin-mediated proteolysis in both signatures, and to other pathways such as the neurotrophin signalling pathway in the ATN-related sncRNA signature (Fig. 3b and Additional file 1: eTable 10) and the mRNA surveillance pathway in the AD-related sncRNA signature (Fig. 3d and Additional file 1: eTable 11). This evidence concerns the gene BDNF and Alzheimer disease.