Overall, the multivariable-adjusted (age, sex, diabetes duration, current smoking, FPG, HbA1c, anti-diabetic therapy, family history of diseases, including diabetes, hypertension, obesity, hyperlipidemia) odd ratios (ORs) for hypertension across ascending quartiles of ALT were 1.00 (reference), 1.267 (95% confidence interval [CI] 0.956–1.677), 1.505 (95% CI 1.114–2.032), and 1.790 (95% CI 1.341–2.388), respectively. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.