Since TM4SF1 has the ability to regulate Akt signaling [26] and ARID1A loss leads to the activation of Akt signaling in lung cancer cells [14], we thus examined whether PLAU and TM4SF1 interaction is involved in the activation of Akt signaling in ARID1A-deficient lung cancer cells. Here, TM4SF1 is linked to lung carcinoma.