To identify novel target genes of ARID1A in malignant diseases, we analyzed 3 GEO datasets that were generated by RNA-sequencing using ARID1A-deficient and control cancer cells: GSE218822 in pancreatic cancer cells, GSE180468 in ovarian cancer cells, and GSE132359 in esophageal squamous cell cancer cells. The gene discussed is ARID1A; the disease is esophageal squamous cell carcinoma.