In this study, we found that TPPP3, C1QA, LGR5, MYH8, CDKN1A gene expression was upregulated, while SLC38A1, SERPINA5, HOXB2 gene expression was downregulated and the AUC value was greater than 0.7 in elderly muscles compared to young people, suggesting that these genes and their encoded proteins have the potential to be diagnostic markers for sarcopenia. This evidence concerns the gene SERPINA5 and sarcopenia.