LDH activity and the expression of HSF1, Hsp70 and Hsp27 decreased in the LS174T and LoVo colorectal adenocarcinoma cell lines (Figs. 2A-D and 3A and B) with lower basal HSP levels, but not in A549 (Figs. 2E-F and 3C), MDA-MB-231 (Figs. 2G-H and 3D) and COLO357 cells (Supplementary Fig. 2A, B, Supplementary Fig. 3). The gene discussed is HSP90B2P; the disease is colorectal adenocarcinoma.