After a treatment with 0.1 and 0.2 mM diclofenac LDH activity and LDHA/B protein levels were significantly reduced in LS174T and LoVo colorectal cancer cells (Fig. 2A-D), but remained unaltered in A549 lung cancer (Fig. 2E, F), MDA-MB-231 breast cancer (Fig. 2G, H) and COLO357 pancreatic cancer cells (Supplementary Fig. 2A, B). This evidence concerns the gene LDHA and familial pancreatic carcinoma.