A globle phase II clinical trial (CITYSCAPER, NCT03563716) of tiragolumab, a humanized anti-TIGIT monoclonal antibody, in combination with the PD-L1 inhibitor atezolizumab for 135 PD-L1-positive patients suffering from NSCLC, was first reported at the 2020 American Society of Clinical Oncology (ASCO) meeting [183], and published recently [20]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.