MAPT and progressive supranuclear palsy: In some cases, specific isoforms can be associated to distinct tauopathies; as an example, 3R-Tau aggregates are commonly found in patients affected by Pick’s disease, 4R-Tau is characteristic of progressive supranuclear palsy (PSP) tangles, while AD patients present aggregates with both 3R- and 4R-Tau isoforms [10].