Among the most studied, Amyloid-β (Aβ), Tau, α-Synuclein (α-Syn) and TAR DNA-binding protein-43 are commonly associated, either alone or in combination, with some major neurodegenerative disorders (NDs), including Alzheimer disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (for a comprehensive review, please see [3]). Here, TARDBP is linked to Alzheimer disease.