As the K-M curves in (Fig. 2) represent, PD1-TC-PD-L1 was a significant OS (0.046) and DFS (P = 0.021) predictor in our study population in such a way that none of the patients with an S2 score (n = 12, 12.6%) experienced recurrence or cancer-caused death during the follow-up time. This evidence concerns the gene CD274 and cancer.