As indicated by the area under the ROC curve, EMP3 showed high diagnostic accuracy for patients with glioma (CGGA EMP3:AUC = 0.762, 95% CI:0.706–0-0.817; TCGA EMP3:AUC = 0.762, 95% CI:0.720–0-0.805, Fig. 3C, D). Here, EMP3 is linked to central nervous system cancer.