Interestingly, EMP3 demonstrated a unique connection with mesenchymal transition specifically in aggressive glioblastoma (Fig. 1A-C), while not showing a similar association in low-grade oligodendroglioma or IDH-mutant astrocytoma (Fig. 1D-E, Supplementary Table 4 & 5) [21, 22]. The gene discussed is EMP3; the disease is astrocytoma (excluding glioblastoma).