BDNF and obesity due to melanocortin 4 receptor deficiency: In the current study, we explored the functional biology of a SNP that had the fifth highest association to obesity (rs10767664; p = 4.69 × 10−26) in a study of 204,158 individuals [5] and which also occurred in a highly conserved region (BE5.1) within intron 3 of the BDNF gene.