We selected Trp53 inactivation, β-catenin activating mutation and MYC overexpression, which are among the most frequently affected oncogenic alterations in human HCC (Zucman-Rossi et al, 2015; Molina-Sánchez et al, 2020; Fig. 1A), as well as the overexpression of cyclin D1 (CCND1), the latter mimicking the focal amplification of 11q13 (encoding both FGF19 and CCND1) observed in 10% of HCC (Sawey et al, 2011). Here, CCND1 is linked to hepatocellular carcinoma.