In our model, the co-expression of FGF15 with MYC also gave rise to hepatic carcinogenesis, albeit within a slightly longer timeframe (7/8 mice exhibited tumors after 4–6 weeks post-HGT) and a lower tumor burden (mean = 10.3) in comparison with FGF19 + MYC (Fig. 1D,E). Here, FGF19 is linked to neoplasm.