Especially, ABLIM1 knockdown dramatically reduced the number and size of metastasis nodules in nude mouse livers (Fig. 2I), and corresponding HE images under microscopy also displayed the significant differences of tumor loci area in livers before and after ABLIM1 knockdown (Supplementary Fig. S3B), suggesting the crucial role of ABLIM1 in CRC invasion and metastasis. The gene discussed is ABLIM1; the disease is neoplasm.