Additionally, CRC cells treated with PS341, a selective proteasome inhibitor, showed a rescued effect on IĸBα protein levels no matter those cells were manipulated with ABLIM1 overexpression or knock-down (Fig. 6C), which implies that the modulation of ABLIM1 on IĸBα degradation should be proteasome-dependent. The gene discussed is ABLIM1; the disease is colorectal carcinoma.