Taken together, as depicted in Fig. 8E, we clarify that ABLIM1 acts as a novel ubiquitin E3 ligase, which interacts with IĸBα via HP domain, promotes IĸBα ubiquitination, and then activates NF-κB/CCL20 signaling, finally leading to the growth and metastasis in CRC. Here, CCL20 is linked to colorectal carcinoma.