RELA and neoplasm: Importantly, the IĸBα/NF-κB blockade by BAY11-7082 further abolished the effect of ABLIM1 overexpression on cell proliferation, migration, and invasion (Fig. 5B–D), implying IĸBα phosphorylation mediated NF-κB p65 activation is involved in the tumor-promoting role of ABLIM1.