These data revealed that Ocn haploinsufficiency in offspring results in hyperglycemia only if their mothers also lack at least one allele of Ocn. When mothers were WT, the amount of maternal osteocalcin passing through the placenta sufficed to prevent any deleterious and long-lasting effect on glucose homeostasis post-natally that Ocn haploinsufficiency in offspring may have caused. Here, BGLAP is linked to Hyperglycemia.