The first locus was observed in our discovery GWAS (n = 25,819) and harbors six sequence variants (lead variant: rs12776883) in an intronic enhancer region of PLPP4. This protein-coding gene is highly expressed in brain, kidneys, and testes43, and has previously been associated with cognitive decline in Alzheimer's and Parkinson's diseases52,53, among other conditions. Here, PLPP4 is linked to Mental deterioration.