CTLA4 and nonpapillary renal cell carcinoma: Notably, CD8+ inflamed tumors are characterized by high CD8+ T cell infiltration, increased expression of PD-1, PD-L1, PD-L2, and CTLA-4, and higher frequency of chromosome 14 loss and BAP1 mutations7, which have been associated with worse prognosis in ccRCC, but hold implications for response to ICI therapy39,40.