To investigate the possibility of additional mechanisms underlying IR-induced ferroptosis promoted by GSTM3, we examined the expressions of several key genes (GPX4, ACSL3, SLC7A11, TF, FTL) involved in the ferroptosis pathways [11, 12] in NPC cells with GSTM3 overexpression. This evidence concerns the gene GPX4 and nasopharyngeal carcinoma.