XDH and ischemic disease: In contrast, the XDH-variant-induced reduction in serum uric acid was not significantly associated with lower odds of AMI (OR, 0.98; 95% CI, 0.89–1.07; P = 0.607), IHD (OR, 0.99; 95% CI, 0.94–1.04; P = 0.667), transient cerebral ischemic attack (OR, 0.98; 95% CI, 0.87–1.11; P = 0.768), or overall ischemic disease (OR, 0.97; 95% CI, 0.93–1.02; P = 0.297) (Fig. 1).