With the observation of elevated Cxcl10 protein secretion in both the BM plasma of C1498-engrafted mice and as well in HSPC-conditioned medium following C1498-EVAML exposure, our data indicate that HSPCs contribute to Cxcl10 secretion in the AML niche. The gene discussed is CXCL10; the disease is acute myeloid leukemia.