LncEPAT was reported to be a functional oncogene in glioblastoma, and lncEPAT silencing increased the expression of cell aging-associated genes, such as CDKN1A, CLUSTERIN, and DKK1, indicating that lncEPAT exerts a repressive function in glioblastoma cell senescence20. This evidence concerns the gene CLU and glioblastoma.