In this regard, we demonstrate that leptin drives mitochondrial function and glycolytic ATP production in triple-negative breast cancer cells (Fig. 3c,d) with different migration capacities and invasive potential64, and more importantly, we reveal that autophagy is a mechanism that regulates leptin-induced metabolic changes responsible for the migratory and invasive potential (Figs. 3c,d, 4c,d,g, 5, Supplementary Fig. S9). This evidence concerns the gene LEP and triple-negative breast carcinoma.