PPARG and premature menopause: In short, we proposed for the first time that MET enhances the anti-inflammatory and anti-oxidative capacity of GCs through the AMPK/PPAR-γ/SIRT1 pathway, ultimately improving GCs' ability to maintain cellular homeostasis, which suggests that AMPK/PPAR-γ-SIRT1 may be a potential target for the treatment of POF.